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Last modified on Wednesday, 21 April 2021 11:00

Hair loss treatments continue to improve. Better formulas and manufacturing for old standbys such as platelet-rich plasma (PRP) are helping guarantee results. Also of note, recent innovations are entering the market; stem cell treatments are showing great promise, as is topical finasteride. Among the new treatments, though, exosomes are showing the greatest potential.

What are Exosomes & How do they help with Hair Loss?

Exosomes are stem cells per say. Instead, they are the building blocks of such. They generate within their cells of origin if the multivesicular body fuses with the cell membrane, thereby releasing intraluminal vesicles as exosomes. These small cellular products contain both RNA and, even of greater import, mRNA; the initiator of protein manufacturing.

These protein building blocks' roles are dependent on their cell of origin. Many act as signalers for bodily functions, such as coagulation, as well as cellular growth to facilitate said bodily functions. Such signaling and growth factors, studies currently show, are a result of the exosome's origin. Near all, however, have a number of useful growth factors/signalers:

  • MIP-1: A recruiter of mononuclear cells
  • VEGF: A stimulator to encourage blood vessel formation
  • SCF: An encourager of stem cell and melanocyte growth
  • FGF: A growth factor that signals cells to encourage biological development
  • TGFß3: A gene variant that, among other things, converts inflammatory T Cells into anti-inflammatory T-Cells

Research into exosomes is happening for a number of purposes; male and female sexual functioning/revitalization, joint regeneration, and facials. Studies into their viability for biomarkers, Lyme disease treatments, and rheumatoid arthritis (RA) are also being looked into. Exosomes from follicular stem cells, the logic goes, facilitate hair growth and can help prevent hair loss.</p

Exosomes Hair Loss
4 months after Adipose Stem Cells and Amniotic Membrane
Exosomes Result For Treating Hair Loss
After 1200 grafts in the hairline

Nutrition vs. Signaling

Nutrition for follicular cells will always be essential. As those following hair restoration also well know, near all outpatient treatments orient towards said nutrition. PRP, cytokine rich plasma (CRP), and stem cell treatments (to the best knowledge of current research) all orient towards invigorating follicles with nutrient concentrates.

Each of the above treatments also contains exosomes, but not nearly in the same concentration as a processed exosome treatment. This is why exosomes are so exciting. WNT pathways are particularly important for stimulating hair growth. Outside of methyl vanillate, though, no treatments directly encourage this pathway. Stem cells are the closest there is to this function but they serve more as a nutrient that also signals cells. Exosomes, on the other hand, are cellular signalers that also nutritionalize cells.

Exosomes for Hair Restoration

Research into exosomes for hair restoration is a new development. Publications regarding such only have surfaced in the past few years. Spring 2019 is when physicians and researchers largely concurred that the treatment type has major potential.

Even so, however, there is still plenty of research necessary. Such is a matter of comparing results, yes, but also finding the best way to manufacture and apply the said treatment. Several options are being explored currently. Further clinical trials may lead to any number of new applications.

Current Delivery Systems

Currently, two delivery methods are being researched. The first is an injection after creating a serum. Said serum is the same as most blood treatments, but requires additional filtration and manufacturing to selectively net and isolate the exosomes. Obviously, beneficial growth factors will also be in the serum but will not be the focus.

The second delivery method is very similar to the first. Instead of traditional injections, however, it almost resembles currently micro-needling; the practice of puncturing the scalp to improve hair retention. The second exosome delivery method is quite similar; the needles, though, are much smaller; 300 μm in diameter at its base and 600 μm tall.

Research, particularly by UCLA, indicates that both injection and micro-needling are viable. Results, though, favor micro-needling. Shaven mice using the micro-needling system regrew their hair in six days while those that received injections grew their hair more slowly.

Currently, surgeons are applying exosome treatments for hair restoration via injection. As time moves on, though, this may change. Microneedling may rise in popularity or another delivery method altogether may crop up.


Exceedingly small, exosomes can cross barriers and carry proteins through barriers too large for cells to cross. This better facilitates signaling and dispersal of nutrients. Both are responsible for the reinvigoration of follicles. This is why exosomes are incredibly exciting for treating hair loss.

Prolonging the Current Hair Cycle

Even of greater note, exosomes also prolong the hair growth cycle. Hair follicles stuck in the telogen phase (resting phase) convert to the anegan (growth phase) and prolong the cycle of such.

This is of critical benefit; as with every part of our body, hair follicles age. Different than many cells, however, follicular cells age with each cycle of growth. It typically requires decades, but as follicular cells enter and leave each phase they begin to change. Miniaturization, or the shrinking and growing brittleness of hair strands, initiates. From there, without treatment, hair strands continue shrinking after each telogen phase until growth ceases in the complete.

Many hair care products and treatments help prolong hair growth. Few, though, are as capable as exosomes. The hair growth cycle remains intact longer while hair strands become thicker and healthier.

Conclusion: Exosomes Are The Top New Treatment For Hair Loss

A promising new treatment, exosomes are proving to have great potential for treating hair loss. The fact is that it may replace every hair restoration therapy available; even hair transplantation. For the time being, though, exosomes is an emerging treatment that requires finessing.

Dr. Cole and other leading researchers are pursuing this new, and perhaps industry-changing, treatment. Already effective, further improvements should lead to even better results. Forhair always puts the patient first. Pursuing, and refining, this new treatment showcases such. We hope to hear from you!

Interested in learning how exosome therapy can be tailored to your needs?

Contact a physician at the FORHAIR clinic today!

Consult with a doctor

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Thank you for sharing the latest article. This is used to increase brand awareness and new technology. people will know about the latest technology exosomes hair therapy to prevent hair loss.

Comment was last edited about 1 year ago by Forhair Anonymous
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Great article on hair loss treatment. PRP hair treatment is enormously beneficial for all men and women who suffer from severe hair loss. It’s really informative blog… keep sharing with us… Thanks

Comment was last edited about 1 year ago by Forhair Srujana
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Are currently doing stem cell treatment in the world then where to do it
And what the platform does

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We offer Exosomes at the Forhair clinic in Atlanta and also at our clinic in New York City. If you live or stay in America then that will work for you and you can book a free consultation, If you are in Europe then Dr. Cole has plans to corporate again in Turkey in the near future, in this case, since there is still coronavirus and the skies are closed for flying, I suggest to be patience and subscribe to receive updates: https://www.forhair.com/free-online-consultation/

Comment was last edited about 1 year ago by Forhair Forhair
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Does Dr. Cole have an office in the Washington, D.C. Area?

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Dr. Cole has an office in Atlanta and New York. If you are from Washington, D.C. Area you can either come to one of the locations i mentioned or have a photo consultation

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At this time, I am considering PRP versus an Exosomes treatment where I live, as travelling now is not preferred. How would you compare an Exosomes treatment versus having CRP and ACell, when I feel comfortable travelling? From your informative page on Exosomes, I would think choosing that over a widely offered (not CRP) PRP would be an easy choice.

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Ideally, a combination of all these treatments (cocktail) with hair transplant surgery will bring the best results, Every patient and every case is different, there is no direct and accurate answer for this, it also depends on the degree of hair loss, patient budget, and many more factors. Some start with topical finasteride and PRP and see great results and if their budget allows them they combine with more options like exosomes.
I will recommend for any patient that consider regenerative medicine to get a free online consultation first, it doesn't cost and there is no obligation: https://www.forhair.com/free-online-consultation/

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