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DR. COLE LIVE: ANTI-AGING, TREATMENT PROGRESS, AND FUE EUROPE

Forhair held its first streamcast recently! Dr. Cole, Dr. Chiara Insalaco, and Dr. Solange Silva, Professor of Dermatology at Estadual University in Rio de Janeiro, spoke about anti-aging strategies for hair retention, promising advancements in treatments, and the upcoming FUE Europe conference, which will show hair transplants live, on April 28th. Read below for highlights of our first broadcast.

ANTI-AGING STRATEGIES FOR HAIR RETENTION

Hair ages with time, leading to shorter duration of the growth cycle and thinner strands. This is due to T cell inflammation, which surfaces during the resting, or telogen, phase of the hair growth cycle. Such inflammation debilitates and eventually kills stem cells responsible for hair growth. The first line of defense against hair loss, therefore, is an early anti-aging regimen that encourages the hair’s growth phase. Prolonging growth, essentially, also prolongs the anagen phase, extending the hair cycle itself. In turn, this diminishes stem cell damage from T cell inflammation.

The best plan of action, therefore, is the earliest. The earlier patients act, the greater chance there is of hair retention, health, and thickness. Products abound that claim to encourage hair growth or otherwise encourage retention. Some are effective, most particularly those with an adequate amount of their ingredient. However, as our StreamCast later examines, there is huge nuance in the preparation of ingredients that encourage hair health and retention. Many products are less effective than they tout or, to cut costs while cashing in, highlight ingredients regardless of their subpar processing and unsubstantial presence in the formula. Some brands are better than others, of course, but such research demands time and word-of-mouth. Vested in the best results possible, Dr. Cole offers numerous solutions and continues researching new options and enhancements for hair retention. As the next segment covers, these innovations are leading to unprecedented results.

TOPICAL FINASTERIDE: OUTSTANDING RESULTS, NO SIDE-EFFECTS

The first FDA-approved oral treatment for pattern baldness, finasteride has a mixed reputation. A large minority of males experience noticeable, but modest, results from the treatment and eight of ten males probably enjoy greater retention. However, there is concern about side effects that include sexual dysfunction and depression. Complicating matters even more, such side effects can both impact the emergence of such issues and/or surface after a long duration of finasteride use. A small minority undergoes such effects, but the risk is enough to deter patients and understandably why. Without question, though, finasteride’s antiandrogen capability is viable therefore so is its ability to prolong hair growth cycles. The solution, as research by Dr. Chiara Insalaco, shows, maybe to apply it topically.

Dr. Insalaco’s research into the effectiveness of topical finasteride is showing remarkable promise. Localization is the treatment’s primary strength; absorbing finasteride from the scalp contains and focuses its effect, unlike oral options that equally spread throughout the body. The patients in Dr. Insalaco’s study are showing exceptional results, particularly in comparison with oral finasteride, without undergoing any of the negative side effects. Look below to see the before and after photos!

Such results from oral finasteride are, for the most part, nonexistent. Research also shows topical finasteride’s effects arrive within a reasonable time. The above after photos range between two and six months. Dr. Insalaco theorizes results depend on the progression of hair loss and its age. As already mentioned, hair loss happens due to T cell inflammation incapacitating and eventually destroying follicular stem cells. The more viable stem cells, the greater a chance of increasing density, growth, and retention.

Of course, processing and formula both matter. Dr. Insalaco personally creates topical finasteride with locally sourced compounds that include 2% finasteride, as it matches 5% in results after six months, and a small amount of minoxidil. One cannot simply powder oral finasteride and apply it to the scalp, as its activator is different. Topical finasteride varies by its source, and patients can expect results will vary as well. Dr. Cole would recommend topical finasteride from Italy. For those in the U.S, he offers prescriptions for a pharmacy in Alabama; one of the few that create it. A number of patients are using topical finasteride but there is no definitive study about its results. Patients see a difference, however, and it should help retention, health, and growth.

STEM CELL THERAPY: UNPRECEDENTED HAIR COUNT INCREASES

Stem cell therapy is an emerging option that offers considerable results. Research shows it increases overall hair density between 24% and 34%, of note unto itself, within 23 weeks. Unprecedented is its effect of consistently increasing hair count. A few treatments can elevate hair count, but only in select circumstances, for select patients, and in small amounts. Stem cell therapy, on the other hand, activates enough follicles to make a very noticeable effect.

The procedure itself entails small biopsies to the scalp, separation of stem cell-bearing tissue and regular adipose, centrifugation of stem cell regions, and injection the day of the procedure and another 60 days after.

Stem cell therapy research is ongoing. Already superior to generic platelet-rich plasma (PRP), a blood treatment that can promote growth, results may increase with further study. We know that stem cell-bearing tissue varies in its type and amount of stem cells, but distinction necessitates further clinical studies. Processing may also change to encourage results. As the StreamCast next covers, Dr. Cole and Dr. Salico’s research into PRP indicates that little differences in its creation can have big impacts.

CRP: FIVE TO EIGHT TIMES MORE POWERFUL THAN GENERIC PRP

Processing makes a huge difference in PRP’s effectiveness. Studies with Dr. Salico show that high platelet count, what most clinics offering PRP claim spur results, is actually less important than the concentration of growth factors and cytokines. Dr. Cole and Dr. Salico used two different machines, Regen and Arthrex, to generate PRP and then tested growth factor count via ELISA as well as charted their effects on patients. Each PRP type’s growth factor counts relative to their effectiveness is profound.

PRP from Arthrex showed far greater growth factor counts and increased patients’ hair density by around 50%. Regen, which had much lower growth factor counts, may have helped retention but still showed a 25% decrease in overall hair density.

Further study shows the PRP’s activator matters a great deal. Platelets not only need to contain growth factors, essential as they are, but to also open their alpha granules and release said growth factors. Calcium gluconate is a go-to activator that, studies show, is more effective than saline. Unheard of is the use of sonication or the practice of using sound to activate alpha granules. Dr. Cole used a soundproof box to administer the noise over half an hour at thirty-second intervals, thereby preventing any overheating of the PRP.

ELISA tests show the resultant serum, cytokine rich plasma (CRP), has five to eight times the growth factors than PRP without sonication. Further research is necessary to measure CRP’s full impact, but it is significantly greater than any current PRP. The growth rate is particularly impressive. Along with greater graft retention, transplant patients injected with CRP enjoy 100% graft growth in four and a half months. Transplant patients with PRP treatments, meanwhile, had to wait a year for 100% activity. We can reasonably expect CRP results for patients without transplants to be similar.

JOIN US IN MALAGA, SPAIN FOR FUE EUROPE FROM APRIL 26TH TO 28TH!

From April 26th to the 28th FUE Europe is hosting its 7th congress in Malaga, Spain. Dr. Insalaco is co-chair with Dr. Christian Bisanga, who also worked with Dr. Cole in the past. Presentations will range considerably. Dr. Insalaco will present on stem cell therapy, as well as showcase patients’ results. Attendees will have the opportunity to learn about the latest in hair restoration, as well as meet some of its more significant contributors. Hair transplants live streams will happen on the third day, an excellent time for doctors entering the field to get a first-hand glimpse of the procedure in action. A global conference, FUE Europe attracts leading experts and innovators across the field.

AUDIENCE QUESTIONS

Below are audience questions Dr. Cole answered on air. They range from treatment suggestions to explanations of the above topics. They go into specific detail and are worth the read for anyone looking to take action on their hair loss.

 Can Dr. Cole Prescribe Topical Finasteride Treatments?

Yes, Dr. Cole prescribes topical finasteride treatments. As mentioned in that section, there is a pharmacy in Arkansas that makes it with finasteride and adds minoxidil. There has been no distinct study of that source, however. Dr. Insalaco’s version is backed by a clinical study but has yet to undergo a review for exportation. This makes it more challenging to obtain from some locations, including the U.S.

Is Regenix Like the Cole System?

Regenix uses light to separate platelets from PRP. There is news of manufacturers creating better systems with heir monocyte concentration than the Arthrex Angel. As of now, machines captures less than 60% of platelets. This translates to needing 120cc for 30cc of PRP and then dilution to 10cc.

Does Topical Finasteride Help with Hair Shedding and Front of the Scalp?

Yes, topical finasteride improves overall hair quality and growth. As for shedding, topical finasteride promotes the anagen cycle, suspending T cell inflammation and therefore stem cell destruction. This prolongs the overall lifespan and health of follicles.

How Soon Do Patients Enjoy Results from Topical Finasteride?

Results from topical finasteride depend on the patient. From the study, one participant gained noticeable results after 2 months but most had results after 3 months. The treatment is evolving and results may appear quicker in time.

CRP or Stem Cell Therapy?

The advantage of CRP’s superior concentration of growth factors superior vascularity, and thereby hair growth. Its results at our clinic are consistently superior to that of generic PRP. Stem cell therapy, on the other hand, is still emerging and has one study documenting results as of now. Patients’ results are very impressive, though, and will be showcased at FUE Europe this April. In the case of selecting just one treatment, however, Dr. Cole recommends CRP. This may change as stem cell therapy further establishes itself.

ENJOY NEWS, FINDINGS, AND PATIENTS’ STORIES ON FUTURE SHOWS!

Anticipate news, announcements, and patient stories in upcoming StreamCasts! As this first showcases, hair restoration is advancing at an unprecedented level. As options increase so do patient questions. One of the leading clinics in hair restoration, Forhair’s emphasis on innovation and top-tier results mirrors its advocacy for patients. Tune into the show to enjoy honest assessments, commentary, and the (slim) chance to see a hair transplant live, yes, but also for cautionary and critical advice.

From unsafe or bogus treatments to dishonest practices from transplant surgeons, there is plenty to be wary of for those seeking hair restoration. Around 40% of Forhair patients come to us for repair prior work from other clinics. We hope our StreamCast, overall, helps viewers navigate the hair restoration industry and find a positive outcome. Questions or comments? Contact Forhair on this page!